Download e-book for iPad: Aging. Oxidative Stress and Dietary Antioxidants by Victor R. Preedy

By Victor R. Preedy

ISBN-10: 0124059333

ISBN-13: 9780124059337

Aging: Oxidative pressure and nutritional Antioxidants bridges the trans-disciplinary divide and covers in one quantity the technological know-how of oxidative tension in getting older and the doubtless healing use of common antioxidants within the vitamin or nutrients matrix. The methods in the technology of oxidative rigidity are defined in live performance with different techniques, similar to apoptosis, cellphone signaling, and receptor mediated responses. This process acknowledges that ailments are frequently multifactorial, and oxidative tension is a unmarried portion of this.

Gerontologists, geriatricians, nutritionists, and dieticians are separated through divergent abilities disciplines that must be bridged with a view to develop preventative in addition to remedy ideas. whereas gerontologists and geriatricians may well examine the underlying techniques of getting older, they're much less more likely to be familiar with the technology of nutrients and dietetics. nevertheless, nutritionists and dietitians are much less conversant with the designated scientific heritage and technology of gerontology. This booklet addresses this hole and brings each one of those disciplines to undergo at the procedures inherent within the oxidative pressure of getting older.

  • Nutritionists can follow info on the topic of mitochondrial oxidative pressure in a single illness to diet-related techniques in one other unrelated sickness
  • Dietitians can prescribe new meals or diets containing anti-oxidants for stipulations proof against traditional pharmacological remedies
  • Dietitians, after studying in regards to the uncomplicated biology of oxidative tension, might be capable of recommend new remedies to their multidisciplinary teams
  • Nutritionists and dietitians will achieve an realizing of mobile signaling and manage to recommend new preventative or healing innovations with anti-oxidant wealthy foods

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Circ Heart Fail 2010;3:306–13. 864785. Razzaque MS. The role of Klotho in energy metabolism. Nat Rev Endocrinol 2012;8:579–87. 75. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45–51. Kurosu H, Yamamoto M, Clark JD, et al. Suppression of aging in mice by the hormone Klotho. Science 2005;309:1829–33. Pedersen L, Pedersen SM, Brasen CL, Rasmussen LM. Soluble serum Klotho levels in healthy subjects.

9 oxidative stress. 9 SUMMARY POINTS • C  ardiovascular disease is a large burden on the population, in terms of lives lost and economic loss. • The aging portion of the population is increasing and is more likely to suffer the effects of cardiovascular decline leading to clinically relevant cardiovascular disease. • Reduced cardiac antioxidant enzyme activity and increased generation of oxidative stress with aging contributes significantly to the risk of cardiovascular disease. • The telomere theory states that telomere attrition, which is increased with oxidative stress and with age, significantly contributes to cardiovascular decline.

Panel (a): Young heart with normal thickness of the myocardium and no compromised function. Panel (b): Young artery with normal sized lumen and vessel wall; adaptive contractility and relaxation is maintained. Panel (c): Aged heart with myocardial hypertrophy; cardiomyocytes are undergoing senescence and thus have compromised function. Hypertrophy and fibrotic tissues will lead to impeded signaling from the sinoatrial node. Panel (d): Aged artery with narrower lumen, increased wall thickness; adaptive contractility and relaxation is lost.

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Aging. Oxidative Stress and Dietary Antioxidants by Victor R. Preedy


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